Download Acute and Chronic Cough by Anthony E. Redington, Alyn H. Morice PDF

By Anthony E. Redington, Alyn H. Morice

A accomplished overview of the clinical and scientific facets of acute and persistent cough, this reference specializes in contemporary advancements in our figuring out of the molecular biology of putative cough receptors, the neural mechanisms occupied with the afferent and efferent limbs, the significant processing of the cough reflex, and peptides and different ingredients which can mediate or modulate the cough reflex. With chapters written through stated gurus within the box, this guide covers present and strength healing brokers, a variety of methodologies to degree cough reflex sensitivity, and medical techniques for the evaluate of continual cough in adults and kids.

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SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR253 mediates its response to hypotonic stress. J Biol Chem 2003; 278: 11520–11527. Vlachova V, Teisinger J, Suankova K, Lyfenko A, Ettrich R, Vyklicky L. Functional role of C-terminal cytoplasmic tail of rat vanilloid receptor 1. J Neurosci 2003; 23:1340–1350. Chyb S, Raghu P, Hardie RC. Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL. Nature 1999; 397:255–259. Shin J, Cho H, Hwang SW, Jung J, Shin CY, Lee SY, Kim SH, Lee MG, Choi YH, Kim J, Haber NA, Reichling DB, Khasar S, Levine JD, Oh U.

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RARs respond to stimuli that evoke cough and fulfill many of the accepted criteria for mediating cough (5,8,14,17,28–30). Further evidence of their role in the cough reflex comes from studies of vagal cooling, which blocks cough at temperatures that selectively abolish activity in myelinated fibers (including RARs) while preserving C-fiber activity (14,29,30). , thromboxane, leukotriene C4 (LTC4), histamine, neurokinins, and methacholine] are ineffective or only modestly effective at evoking cough (14,31–34).

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